ChonBlock Detection Antibody Dilution

ChonBlock Detection Antibody Dilution 

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Topoisomerase I Dilution Buffer
TG4095	1ml	EUR 187.2

ChonBlock Western Blot Buffer 1 (PBS)
9069P	10 ml	EUR 232.26
Description: ChonBlock Western Blot Buffer 1 (PBS)

ChonBlock Western Blot Buffer 1 (TBS)
9069T	10 ml	EUR 232.26
Description: ChonBlock Western Blot Buffer 1 (TBS)

Dilution buffer R (10x); ELISPOT
CT348	10 ml	EUR 93.6

Dilution buffer T (10x); ELISPOT
CT358	8 ml	EUR 93.6

Antibody Dilution Buffer for ICC and IHC
SF40010	10 ml	EUR 146.4

West-Ezier Antibody Dilution Buffer, ready-to-use
W3872-050	500ml	EUR 198

Dilution Buffer [1x PBS pH 7.3]
0209B	100 ml	EUR 92.4

Dilution buffer B (10x); ELISPOT (PVDF)
CT364	8 ml	EUR 93.6

TnI (Detection) Antibody
abx018057-100ug	100 ug	EUR 410.4

CK19 (Detection) Antibody
abx019246-1mg	1 mg	EUR 794.4

PCT (Detection) Antibody
20-abx019248	EUR 469.20 EUR 744.00	0.5 mg 1 mg

ChonBlock Western Blot Buffer 2 for Goat (PBS)
90691P	10 ml	EUR 145.26
Description: ChonBlock Western Blot Buffer 2 for Goat (PBS)

ChonBlock Western Blot Buffer 2 for Goat (TBS)
90691T	10 ml	EUR 145.26
Description: ChonBlock Western Blot Buffer 2 for Goat (TBS)

ChonBlock Western Blot Buffer 2 for Rabbit (PBS)
90692P	10 ml	EUR 145.26
Description: ChonBlock Western Blot Buffer 2 for Rabbit (PBS)

ChonBlock Western Blot Buffer 2 for Rabbit (TBS)
90692T	10 ml	EUR 145.26
Description: ChonBlock Western Blot Buffer 2 for Rabbit (TBS)

DILUTION SOLUTION WITH HEPES, WITHOUT HUMAN SERUM ALBUMIN
99-783-CM	1 L /pk	EUR 75.6
Description: Specialty Media; Islet products

Anti-ST2 Detection Antibody
A2099-100	100 µg	EUR 435.6

PCT (Detection) Antibody (Biotin)
abx019264-1mg	1 mg	EUR 1078.8

Albumin (Capture / Detection) Antibody
abx019293-1mg	1 mg	EUR 661.2

Albumin (Capture / Detection) Antibody
abx019294-1mg	1 mg	EUR 661.2

Fetal Fibronectin (Detection) Antibody
abx019300-1mg	1 mg	EUR 744

Fetal Fibronectin (Detection) Antibody
abx019302-1mg	1 mg	EUR 744

SCCA1 (Capture / Detection) Antibody
abx019308-1mg	1 mg	EUR 794.4

SCCA1 (Capture / Detection) Antibody
abx019309-1mg	1 mg	EUR 794.4

Mouse IgG Isotype control; Concentrate Minimum 1:50 dilution
NG903C	1 ml	EUR 373.2

Anti-CK-MB Detection Antibody
A2089-100	100 µg	EUR 417.6

Anti-D-Dimer Detection Antibody
A2090-100	100 µg	EUR 405.6

Anti-D-Dimer Detection Antibody
A2091-100	100 µg	EUR 405.6

Anti-Lp-PLA2 Detection Antibody
A2095-100	100 µg	EUR 435.6

Alpha-fetoprotein, AFP (Detection) Antibody
abx019292-1mg	1 mg	EUR 627.6

Senescence Detection Kit
55R-1370	250 tests	EUR 854.4
Description: Senescence Detection Kit for use in the research laboratory

HMGB1 Detection Kit
6010	1 kit	EUR 903.9
Description: HMGB1 Detection Kit

SEB Detection Kit
6030	1 kit	EUR 663.78
Description: SEB Detection Kit

OVA Detection ELISA
6032	1 kit	EUR 663.78
Description: OVA Detection ELISA

NGAL (Detection Ab)
abx019242-100ug	100 ug	EUR 777.6

Detection Reagent A
abx296004-120ul	120 ul	EUR 385.2

Autophagy Detection Kit
abx299014-50tests	50 tests	EUR 627.6

Autophagy Detection Kit
abx299015-200tests	200 tests	EUR 1045.2

Apoptosis Detection Kit
ANXVKB-100T	100 test	EUR 557.64

Apoptosis Detection Kit
ANXVKCFB-100T	100 test	EUR 495.24

Apoptosis Detection Kit
ANXVKCFB7-100T	100 test	EUR 495.24

Apoptosis Detection Kit
ANXVKDY-100T	100 test	EUR 467.16

Apoptosis Detection Kit
ANXVKF-100T	100 test	EUR 395.4

Apoptosis Detection Kit
ANXVKF7-100T	100 test	EUR 395.4

Apoptosis Detection Kit
ANXVKPE-100T	100 test	EUR 415.68

GenomeCoV19 Detection Kit
G628	100 Rxns	EUR 384
Description: The most affordable qPCR Detection Kit for SARS-CoV-2 on the market.abm’s GenomeCoV19 Detection Kit is a real-time reverse transcription-polymerase chain reaction (RT-qPCR) test intended for the qualitative detection of RNA from SARS-CoV-2 in human nasopharyngeal and oropharyngeal swab specimens from individuals suspected of COVID-19 by their healthcare provider. Our GenomeCoV19 Detection Kit is the most affordable qPCR detection kit on the market at only $1.77 USD/test (limited time pricing for US customers only).This kit is widely used in Europe under the CE-IVD certification and is listed by U.S. Food and Drug Administration (FDA) for distribution in the USA, under Section IV.C.

GenomeCoV19 Detection Kit
G628.v2	100 Rxns	EUR 384
Description: The most affordable qPCR Detection Kit for SARS-CoV-2 on the market.abm’s GenomeCoV19 Detection Kit is a real-time reverse transcription-polymerase chain reaction (RT-qPCR) test intended for the qualitative detection of RNA from SARS-CoV-2 in human nasopharyngeal and oropharyngeal swab specimens from individuals suspected of COVID-19 by their healthcare provider. Our GenomeCoV19 Detection Kit is the most affordable qPCR detection kit on the market at only $1.77 USD/test (limited time pricing for US customers only).This kit is widely used in Europe under the CE-IVD certification and is listed by U.S. Food and Drug Administration (FDA) for distribution in the USA, under Section IV.C.

Formaldehyde Detection Kit
K001-F1	2x96 well plate	EUR 510

Senescence Detection Kit
K2030-250	250 Staining	EUR 552

Senescence Detection Kit
K320-250		EUR 561.6

IRAK Detection Set
PSI-1802	1 Set	EUR 884.4
Description: Members of the IRAK (IL-1R-associated kinase)/Pelle family play a major role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK and IRAK-2 regulate the activity of a signaling cascade that mediates the activation of NF-κB and MAP kinase. IRAK-4 interacts with and phosphorylates IRAK, while IRAK-M is thought to inhibit the recruitment and activation of IRAK-4 and IRAK. The importance of the IRAK family in inflammation and immunity is illustrated by the fact that animals lacking IRAK-4 are impaired in their responses to viral and bacterial challenges and are completely resistant to LPS challenge.;;For images please see PDF data sheet

TLR Detection Set
PSI-1806	1 Set	EUR 1627.8
Description: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include MyD88, TIRAP, TIRP, TOLLIP, and TRIF. These molecules interact with and activate the IL-1R-associated kinase (IRAK) family, which then activates TNF receptor associated factor (TRAF)-6, and ultimately leads to the activation of NF-κB. While most TLRs utilize more than one adaptor, certain adaptor molecules are essential for individual TLR signaling, e.g., TLR4 signaling is dependent on TIRP expression.;;For images please see PDF data sheet

ORAI Detection Set
PSI-1819	1 Set	EUR 1627.8
Description: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. The ORAI family is a recently identified set of proteins that are essential components of these CRAC channels. A missense mutation in the ORAI1 protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with the stromal interaction molecule 1 (STIM1), the store-activated endoplasmic reticulum Ca++ sensor. Like ORAI1, ORAI2 also functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, although at a lesser efficacy than ORAI1. Although ORAI3 can also function as Ca++ plasma membrane channel, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. STIM1, in its function as a Ca++ sensor and an activator of CRAC channels, migrates to the plasma membrane from endoplasmic reticulum-like sites which act as cellular Ca++ stores. A related molecule, STIM2, inhibits the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting these two proteins may play a coordinated role in controlling Ca++ entry. The ORAI antibodies are predicted to have no cross-reactivity to the other ORAI proteins. Similarly, the STIM antibodies will not cross-react with the other STIM protein.;;For images please see PDF data sheet

Grik Detection Set
PSI-1824	1 Set	EUR 1627.8
Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and Grik5/KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Grik2, also known as glutamate receptor 6, may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. Grik3, also known as glutamate receptor 7, has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Grik4 codes for the KA1 subunit of kainate-type ionotropic gluatamate receptors; mutations in this gene show significant association with both schizophrenia and bipolar disorder. Grik5, also known as kainate-preferring glutamate receptor subunit KA2, does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface. ;;For images please see PDF data sheet

SAPAP Detection Set
PSI-1826	1 Set	EUR 752.1
Description: The members of the SAP90/PSD-95-associated protein (SAPAP) family (also known as the DLGAP family) specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. The SAPAP proteins are thought to be adaptor proteins that also interact with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1, -2 and -4 mRNA are targeted to cell bodies, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM). SAPAP3 protein is targeted to dendrites. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. Multiple isoforms of the SAPAP proteins are known to exist.;;For images please see PDF data sheet

Junctophilin Detection Set
PSI-1828	1 Set	EUR 752.1
Description: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH1 is essential for stabilizing the T-tubule and SR membranes to form junctions and provide an environment for the assembly of receptors such as the ryanodine receptor type 1 (RyR1). JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. Multiple isoforms of the JPH proteins are known to exist.;;For images please see PDF data sheet

Matrillin Detection Set
PSI-1830	1 Set	EUR 752.1
Description: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of MATN1 have been associated with variety of inherited chondrodysplasias, while aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms. The MATN1 promoter region has also been shown to be associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis. Other studies indicate that MATN2 is a permissive substrate for axonal growth and cell migration, and it is required for successful nerve regeneration, while MATN4 could serve as an odontoblast differentiation marker, e.g. in odontoblast stem cell research.;;For images please see PDF data sheet

Ubiquitin Detection Kit
SKT-131-20	20 assays	EUR 594
Description: Purification Detection kit used to capture, detect, identify and characterise ubiquitinated proteins and free chains from samples. in Cell Lysates, Tissue samples from all species

Glutathione Detection Kit
SKT-202-96	1 plate of 96 wells	EUR 513.6
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

PDL1 Detection Set
SD8500	1 Set	EUR 355.2
Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

PD1 Detection Set
SD8600	1 Set	EUR 537.9
Description: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

LAG3 Detection Set
SD8700	1 Set	EUR 569.4
Description: The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

TIGIT Detection Set
SD8800	1 Set	EUR 569.4
Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Mouse Total IgG Antibody Detection Kit
3023	1 kit	EUR 580.26
Description: Mouse Total IgG Antibody Detection Kit

Mouse Total IgM Antibody Detection Kit
3024	1 kit	EUR 580.26
Description: Mouse Total IgM Antibody Detection Kit

Mouse Total IgG1 Antibody Detection Kit
3025	1 kit	EUR 580.26
Description: Mouse Total IgG1 Antibody Detection Kit

Mouse Total IgG2a Antibody Detection Kit
3026	1 kit	EUR 580.26
Description: Mouse Total IgG2a Antibody Detection Kit

Mouse Total IgG2b Antibody Detection Kit
3027	1 kit	EUR 580.26
Description: Mouse Total IgG2b Antibody Detection Kit

Mouse Total IgG3 Antibody Detection Kit
3028	1 kit	EUR 580.26
Description: Mouse Total IgG3 Antibody Detection Kit

Mouse Total IgA Antibody Detection Kit
3019	1 kit	EUR 580.26
Description: Mouse Total IgA Antibody Detection Kit

Coronavirus IgM/IgG Antibody Detection Card
K1463-100	100 Tests	EUR 1578

Coronavirus IgM/IgG Antibody Detection Card
K1463-25	25 Tests	EUR 502.8

Coronavirus IgM/IgG Antibody Detection Card
K1463-50	50 Tests	EUR 879.6

MitoCapture Apoptosis Detection Kit
55R-1305	25 assays	EUR 332.4
Description: Apoptosis Kit for detection of apoptosis in the research laboratory

Mouse Albumin Detection Kit
3012	1 kit	EUR 580.26
Description: Mouse Albumin Detection Kit

Rat Albumin Detection Kit
3020	1 kit	EUR 580.26
Description: Rat Albumin Detection Kit

Protein A Detection Kit
abx090813-1Kit	1 Kit	EUR 1897.2

Luciferase Mycoplasma Detection Kit
20-abx098882	EUR 1479.60 EUR 627.60 EUR 777.60	200rxns 25 rxns 50 rxns

PCR Mycoplasma Detection Kit
abx098883-100rxns	100 rxns	EUR 644.4

D-Dimer (Detection Ab)
abx019237-1mg	1 mg	EUR 644.4

NT-proBNP (Detection Ab)
abx019244-1mg	1 mg	EUR 828

Luciferase Mycoplasma Detection Kit
20-abx298016	EUR 1212.00 EUR 360.00 EUR 510.00	200 rxns 25 rxns 50 rxns

PCR Mycoplasma Detection Kit
abx298017-100rxns	100 rxns	EUR 376.8

Residual SDS Detection Kit
BSP055	100Assays	EUR 99.67

GST Detection Reagent, 1EA
C035-1EA	1EA	EUR 284.4

Hemoglobin Detection Reagent, 20ML
C038-20ML	20ML	EUR 309.6

Fluorescent Detection Reagent, 5ML
C116-5ML	5ML	EUR 321.6

PCR Mycoplasma Detection Kit
M034-Kit	Kit	EUR 319.2

Mycoplasma Detection Kit (OKSB00010)
OKSB00010	50 Tests	EUR 458.4
Description: Description of target: ;Species reactivity: ;Application: PCR;Assay info: ;Sensitivity:

MitoStep + Apoptosis Detection Kit
KMAF-100T	100 test	EUR 504.6

MitoStep + Apoptosis Detection PE
KMAPE-100T	100 test	EUR 551.4

Senescence Detection Kit (Fluorometric)
K991-100		EUR 861.6

PCR-Salmonella Detection Kit
K1447-96		EUR 744

PCR-STEC Detection Kit
K1452-96		EUR 940.8

PCR-Campylobacter Detection Kit
K1453-96		EUR 940.8

Instant Lentivirus Detection Card
K1470-10	10 tests	EUR 454.8

Instant Lentivirus Detection Card
K1470-20	20 tests	EUR 636

Mycoplasma PCR Detection Kit
K1476-100	100 Rxns	EUR 357.6

Thiol Fluorescent Detection Kit
K005-F1	1x96 well plate	EUR 381.6

Glutathione Fluorescent Detection Kit
K006-F1	1x96 well plate	EUR 424.8

DNA Methylation Detection Kit
K5082100	1 kit	EUR 412.8

TLR Adaptor Detection Set
PSI-1807	1 Set	EUR 884.4
Description: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include MyD88, TIRAP, TIRP, TOLLIP, and TRIF. These molecules interact with and activate the IL-1R-associated kinase (IRAK) family, which then activates TNF receptor associated factor (TRAF)-6, and ultimately leads to the activation of NF-κB. While most TLRs utilize more than one adaptor, certain adaptor molecules are essential for individual TLR signaling, e.g., TLR4 signaling is dependent on TIRP expression.;;For images please see PDF data sheet

SARS Protein Detection Set
PSI-1810	1 Set	EUR 884.4
Description: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral S (Spike) protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. The M protein (Membrane protein, Matrix protein) is another major structural viral protein. It is an integral membrane protein involved in the budding of the viral particles and interacts with S protein and the nucleocapsid protein. The SARS E protein contains a short palindromic transmembrane helical hairpin that seems to deform lipid bilayers, which may explain its role in viral budding and virion envelope morphogenesis. ACE2, the SARS receptor, normally plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis.;;For images please see PDF data sheet

Anthrax Protein Detection Set
PSI-1811	1 Set	EUR 884.4
Description: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2). PA is cleaved into two fragments by a furin-like protease after receptor binding. The bound fragment binds both LF and EF; the resulting complex is then endocytosed into the cell which allows the release of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the infected organism. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis . EF is a calmodulin and Ca++-dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system. The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis in addition to its role as the anthrax toxin receptor.;;For images please see PDF data sheet

Autophagy Protein Detection Set
PSI-1813	1 Set	EUR 884.4
Description: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. PIST is a protein that interacts with Beclin-1 through its coiled-coil domain and can modulate Beclin-1 activity. LAMP1 and LAMP2 are homologous, highly glycosylated proteins associated with the lysosome and are thought to have overlapping functions. Mice lacking LAMP1 have very minor defects compared to those deficient in LAMP2 expression. However, the loss of both proteins results in embryonic lethality, suggesting that each protein possesses some unique and necessary functions.;;For images please see PDF data sheet

Ubiquitin Interact Detection Kit
SKT-132-20	20 assays	EUR 556.8
Description: Purification Detection kit used to capture, detect, identify and characterise isolated ubiquitin binding proteins by Western blotting or proteomic analysis in samples. in Cell Lysates, Tissue samples from all species

Urine Creatinine Detection Kit
SKT-200-192	2 plates of 96 wells	EUR 410.4
Description: Direct Detection kit used for quantitative measuring creatinine in Urine samples from Human, Monkey, Dog, Rat

Nitric Oxide Detection Kit
SKT-212-96	2 plates of 96 wells	EUR 410.4
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Hydrogen Peroxide Detection Kit
SKT-216-192	2 plates of 96 wells	EUR 529.2
Description: Direct Colorimetric assay used for quantitative measuring H2O2 in a variety of samples in Urine, Buffer, Tissue Culture Media samples from all species

Creatinine Serum Detection Kit
SKT-217-192	2 plates of 96 wells	EUR 410.4
Description: Direct Colorimetric assay used to measure creatinine in Serum, Plasma samples from Human, Mouse, Rabbit, Rat, Sheep

QuantiFluo ALP Detection Reagent
QFALP-6mL	600	EUR 187.2
Description: A stable 4-methylumbelliferyl phosphate (MUP) liquid substrate reagent formulated for detecting alkaline phosphatase ALP, e.g. in ELISA. This single reagent produces a highly fluorescent product (360/450 nm) when dephosphorylated by ALP. The fluorescent p

QuantiFluo HRP Detection Reagent
QFHRP-25mL	500	EUR 291.6
Description: A stable 10-Acetyl-3,7-dihydroxyphenoxazine (also called Ampliflu Red) liquid substrate reagent formulated for detecting horseradish peroxidase HRP activity, e.g. in ELISA. This reagent produces a highly fluorescent product (530/590nm) upon reaction with

Detection Reagent Concentrate, 1ML
X041-1ML	1ML	EUR 171.6

Anti-Troponin I (27-73) Detection Antibody
A2105-100	100 μg	EUR 381.6

Anti-Troponin I (27-40) Detection Antibody
A2106-100	100 µg	EUR 381.6

Anti-NT-proBNP (61-76) Detection Antibody
A2113-100	100 µg	EUR 381.6

Anti-NT-proBNP (12-16) Detection Antibody
A2115-100	100 µg	EUR 454.8

Mouse CCL28 Detection Assay Kit
6724	1 kit	EUR 580.26
Description: Mouse CCL28 Detection Assay Kit

Mouse CXCL1 Detection Assay Kit
6725	1 kit	EUR 580.26
Description: Mouse CXCL1 Detection Assay Kit

Mouse CXCL14 Detection Assay Kit
6727	1 kit	EUR 580.26
Description: Mouse CXCL14 Detection Assay Kit

Human CCL5 Detection Assay Kit
6822	1 kit	EUR 580.26
Description: Human CCL5 Detection Assay Kit

Human CXCL1 Detection Assay Kit
6825	1 kit	EUR 580.26
Description: Human CXCL1 Detection Assay Kit

TUNEL FITC Apoptosis Detection Kit
A111-01	20 rxn	EUR 339.6

TUNEL FITC Apoptosis Detection Kit
A111-02	50 rxn	EUR 490.8

TUNEL FITC Apoptosis Detection Kit
A111-03	100 rxn	EUR 646.8

TUNEL BrightGreen Apoptosis Detection Kit
A112-01	20 rxn	EUR 367.2

TUNEL BrightGreen Apoptosis Detection Kit
A112-02	50 rxn	EUR 547.2

TUNEL BrightGreen Apoptosis Detection Kit
A112-03	100 rxn	EUR 786

TUNEL BrightRed Apoptosis Detection Kit
A113-01	20 rxn	EUR 367.2

TUNEL BrightRed Apoptosis Detection Kit
A113-02	50 rxn	EUR 547.2

TUNEL BrightRed Apoptosis Detection Kit
A113-03	100 rxn	EUR 786

Platelet Associated Immunoglobulin Detection Kit
abx290001-25assays	25 assays	EUR 1161.6

Platelet Associated Immunoglobulin Detection Kit
abx290001-50Assays	50 Assays	EUR 1429.2

Alkaline Phosphatase Live Detection Kit
20-abx298024	EUR 427.20 EUR 610.80	25 ul 50 ul

ThioStar® Detection Reagent, 1EA
C012-1EA	1EA	EUR 278.4

PdX? Palladium Detection Reagent, 3ML
C017-3ML	3ML	EUR 621.6

ThioStar® Detection Reagent, 1EA
C036-1EA	1EA	EUR 768

ThioStar® Detection Reagent, 1EA
C048-1EA	1EA	EUR 309.6

ThioStar® Detection Reagent, 1EA
C053-1EA	1EA	EUR 309.6

HISTAR DETECTION SYSTEM Kits (OKSA11259)
OKSA11259	50 Tests	EUR 678
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity:

HISTAR DETECTION SYSTEM Kits (OKSA11260)
OKSA11260	150 Tests	EUR 1602
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity:

HISTAR DETECTION SYSTEM Kits (OKSA11261)
OKSA11261	500 Tests	EUR 2422.8
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity:

Mitochondrial Apoptosis Detection Fluorometric Kit
K2097-100	100 assays	EUR 602.4

Mitochondrial Apoptosis Detection Fluorometric Kit
K2097-25	25 assays	EUR 285.6

Copper Detection Assay Kit (Fluorometric)
K899-100		EUR 548.4

PCR-Salmonella-Listeria Detection Kit
K1448-96		EUR 940.8

CRISPR Genomic Cleavage Detection Kit
K1250-25		EUR 483.6

PCR-Listeria monocytogenes Detection Kit
K1449-96		EUR 777.6

PCR-Legionella spp Detection Kit
K1450-96		EUR 777.6

CRISPR Genomic Cleavage Detection Kit
G932	25 Reactions	EUR 246

Cholesterol Detection Kit (cell-based)
K587-100		EUR 352.8

TRAIL and Receptor Detection Set
PSI-1801	1 Set	EUR 884.4
Description: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organism. It is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family which is expressed in a variety of human tissues. Similar to TNF and Fas ligand, TRAIL induces apoptosis and NF-κB activation in many tissues and cells. Its receptors include the death domain containing proteins DR4 and DR5, both of which mediate TRAIL induced cell death. Two decoy receptors, DcR1 and DcR2, have also been identified. Both of these proteins contain an extracellular TRAIL binding domain but lack intracellular signaling domains. Overexpression of either DcR1 or DcR2 attenuates TRAIL-induced apoptosis.;;For images please see PDF data sheet

BAFF and Receptor Detection Set
PSI-1803	1 Set	EUR 884.4
Description: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members were recently identified by several groups and designated BAFF and APRIL. Both proteins stimulate B cell proliferation, humoral immune responses, NF-κB activation, and apoptosis. Two receptors, TACI and BCMA, recognize both BAFF and APRIL; a third receptor, BAFF-R, is specific for BAFF. These ligands and their receptors are involved in the development of autoimmune diseases as well as cancer.;;For images please see PDF data sheet

TOR Signaling Pathway Detection Set
PSI-1805	1 Set	EUR 1287.6
Description: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle progression through its ability to integrate signals from nutrient levels and growth factors. TOR regulation is accomplished through a network of various activators and repressors. It is phosphorylated by Akt, whose activity is indirectly inhibited by the lipid phosphatase PTEN. TOR is normally associated with the regulatory proteins RAPTOR, a scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation, and GΒL, which stimulates TOR’s kinase activity towards downstream proteins. It is further regulated by the proteins Rheb, TSC1 and TSC2, which act to modulate TOR activity. The downstream targets of TOR are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs) whose activation leads to increased protein translation and cell growth.;;For images please see PDF data sheet

ER Signaling Protein Detection Set
PSI-1814	1 Set	EUR 752.1
Description: The endoplasmic reticulum (ER) is an organelle composed of an interconnected network of tubules, vesicles and cisternae found in all eukaryotic cells. It is involved in several specialized processes such as protein translation, folding, and transport of proteins to be used in the cell membrane or secreted from the cell. Accumulation of malfolded proteins in the ER activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase, to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA, converting it to a potent UPR transcriptional activator. ER stress also causes the cleavage of ATF6, yielding a cytosolic fragment which migrates to the nucleus and together with XBP-1, activates transcription of UPR-responsive genes. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.;;For images please see PDF data sheet

BH3-Only Protein Detection Set
PSI-1816	1 Set	EUR 1287.6
Description: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. This process is regulated by the interplay of pro- and anti-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family. The BH3-only (Bcl-2-homology domain 3 only) proteins are a pro-apoptotic subgroup of the Bcl-2 family that are critical initiators of lymphocyte apoptosis and other processes. Unlike the other members of the Bcl-2 family which contain at least two Bcl-2 homology (BH) domains, these proteins contain just one, the BH3 domain. Some of the members of this family, such as Hrk, may show little sequence homology to the others, but all BH-only proteins can bind to at least some pro-survival Bcl-2-like proteins through this BH3 domain and trigger apoptosis when overexpressed. For example, the proteins Bad, Bim and Bmf regulate apoptosis by forming heterodimers with the anti-apoptotic proteins Bcl-2 and Bcl-xL. Bim, Noxa, and PUMA are activated by p53 following DNA damage although the exact mechanisms are not entirely clear. Noxa may also be involved with the activation of Bik, a BH3-only protein whose localization in the endoplasmic reticulum (ER) suggests that Bik may play a role in ER-stress-induced apoptosis. While full-length Bid also promotes apoptosis when expressed, its activity is enhanced following cleavage by enzymes such as capsase-8, suggesting that Bid may play a key role in death-receptor induced apoptosis.;;For images please see PDF data sheet

Retrovirus Restriction Factor Detection Set
PSI-1817	1 Set	EUR 1287.6
Description: Mammalian cells have developed multiple strategies to limit retroviral infection including numerous proteins termed restriction factors that restrict retrovirus replication and infection. One such protein is TRIM5, a member of a broad family of otherwise unrelated proteins whose longest isoform, TRIM5α, enables resistance to infection by HIV-1 through rapid degradation of HIV-1 Gag polyproteins. Another protein, APOBEC3G (and to a lesser extent APOBEC3F) can be incorporated into HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity. The human uracil-DNA glycosylase UNG2 can also be incorporated into the HIV-1virion, indicating that it is required to remove uracils from the viral genome. It has been suggested that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome. UNG1, the mitochondrial form of UNG, is transcribed from the same gene as UNG2 through differentially regulated promoters and alternative splicing, but does not appear to have anti-retroviral properties. AID, a protein related to APOBEC3 also possesses cytidine deaminase activity that can be blocked by the HIV-1 Vif protein in E. coli, but so far it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.;;For images please see PDF data sheet

Death Domain Receptor Detection Set
PSI-1825	1 Set	EUR 1287.6
Description: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis can be induced by certain cytokines such as TNF-a and Fas ligand. Apoptosis-inducing signals are often mediated by receptors containing so-called "death domains” in their cytoplasmic domains. These proteins include DR3 (also known as TNFRSF25), DR4 (also known as TNFRSF10A), DR5 (also known as TNFRSF10B), and DR6 (also known as TNFRSF21). DR3 is highly expressed in the tissues enriched in lymphocytes including thymus and spleen and may play a role in regulating lymphocyte homeostasis. DR4 is also called TRAIL receptor-1 (TRAIL-R1) and is expressed in most of human tissues. DR5, also known as TRAIL-R2, is widely expressed in normal tissues and in many types of tumor cells. Like DR5, DR6 is also widely expressed, and has recently been suggested to play a role in the pathogenesis of Alzheimer’s disease. ;;Two decoy receptors for TRAIL have been identified and designated DcR1 (also known as TNFRSF10C) and DcR2 (TNSRSF10D). DcR1 is a glycophospholipid-anchored cell surface protein with an extracellular TRAIL-binding domain but lacking an intracellular signaling domain. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis. DcR2 also has an extracellular TRAIL-binding domain but lacks the intracellular death domain and does not induce apoptosis. Similar to DcR1, overexpression of DcR2 attenuated TRAIL-induced apoptosis. Another decoy receptor, DcR3 (also known as TNFRSF6B) exists as a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis.;;For images please see PDF data sheet

PCRAgH5 AIV Detection Test Kit
PD55-02	1 kit	EUR 1082.96
Description: Please check the datasheet of PCRAgH5 AIV Detection Test Kit before using the test.

Blood Urea Nitrogen Detection Kit
SKT-213-192	2 plates of 96 wells	EUR 513.6
Description: Direct Colorimetric assay used for quantitative measuring urea nitrogen in a variety of samples in Serum, Plasma, Urine, Saliva, Tissue Culture Media samples from all species

PD1 Detection Set (Risk Free)
RF16000	1 Set	EUR 537.9
Description: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

CTLA4 Detection Set (Risk Free)
RF16010	1 Set	EUR 342.6
Description: The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2). Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3). Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4). CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5).ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

PDL2 Detection Set (Risk Free)
RF16020	1 Set	EUR 474.9
Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through an alternative receptor from PD-1.ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

PDL1 Detection Set (Risk Free)
RF16030	1 Set	EUR 600.9
Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

ChonBlock Detection Antibody Dilution