Pak4 siRNA/shRNA/RNAi

Pak4 siRNA/shRNA/RNAi 

To Order Contact us: lieven@wlsolutions.be

pROKII- RNAI Plasmid
PVT3202	2 ug	EUR 319.2

Human p21 Protein Activated Kinase 4 (PAK4) ELISA Kit
DLR-PAK4-Hu-48T	48T	EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human p21 Protein Activated Kinase 4 (PAK4) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human p21 Protein Activated Kinase 4 (PAK4) ELISA Kit
DLR-PAK4-Hu-96T	96T	EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human p21 Protein Activated Kinase 4 (PAK4) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human p21 Protein Activated Kinase 4 (PAK4) ELISA Kit
RD-PAK4-Hu-48Tests	48 Tests	EUR 625.2

Human p21 Protein Activated Kinase 4 (PAK4) ELISA Kit
RD-PAK4-Hu-96Tests	96 Tests	EUR 867.6

Human p21 Protein Activated Kinase 4 (PAK4) ELISA Kit
RDR-PAK4-Hu-48Tests	48 Tests	EUR 652.8

Human p21 Protein Activated Kinase 4 (PAK4) ELISA Kit
RDR-PAK4-Hu-96Tests	96 Tests	EUR 907.2

GeneGlide? RNAi Delivery Control
M1082-10		EUR 284.4

GeneGlide? RNAi Delivery Control
M1082-100		EUR 1002

GeneGlide? RNAi Delivery Control
M1082-50		EUR 594

T7 RNAi Transcription Kit
TR102-01	25 rxn	EUR 307.2

T7 RNAi Transcription Kit
TR102-02	50 rxn	EUR 484.8

PAK4 antibody
70R-11829	100 ug	EUR 483.6
Description: Rabbit polyclonal PAK4 antibody

PAK4 antibody
70R-50787	100 ul	EUR 344.4
Description: Purified Polyclonal PAK4 antibody

PAK4 antibody
70R-19098	50 ul	EUR 522
Description: Rabbit polyclonal PAK4 antibody

PAK4 antibody
38462-100ul	100ul	EUR 302.4

PAK4 Antibody
3077-002mg	0.02 mg	EUR 206.18
Description: PAK4 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.

PAK4 Antibody
3077-01mg	0.1 mg	EUR 523.7
Description: PAK4 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.

PAK4 Peptide
3077P	0.05 mg	EUR 197.7
Description: (IN) PAK4 peptide

PAK4 protein
30R-2822	5 ug	EUR 603.6
Description: Purified recombinant Human PAK4 protein

PAK4 Antibody
35447-100ul	100ul	EUR 468

PAK4 Antibody
35864-100ul	100ul	EUR 302.4

PAK4 Antibody
3444-100		EUR 398.4

PAK4 Antibody
3444-30T		EUR 175.2

PAK4 antibody
20R-1576	100 ug	EUR 807.6
Description: Rabbit polyclonal PAK4 antibody

PAK4 Antibody
24183-100ul	100ul	EUR 468

PAK4 Antibody
ABD7078	100 ug	EUR 525.6

PAK4, Active
7707-5		EUR 444

PAK4 Antibody
1-CSB-PA05437A0Rb	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:500

PAK4 Antibody
DF7078	200ul	EUR 420

PAK4 Antibody
1-CSB-PA038167	EUR 380.40 EUR 292.80	100ul 50ul
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PAK4 Antibody
1-CSB-PA006475	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.IHC:1/200-1/1000.ELISA:1/40000

PAK4 Antibody
1-CSB-PA017408GA01HU	EUR 716.40 EUR 399.60	150ul 50ul
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

anti-PAK4
YF-PA25539	50 ul	EUR 400.8
Description: Mouse polyclonal to PAK4

pAd/BLOCK-iT-DEST RNAi Gateway Vector
PVT12297	2 ug	EUR 1342.8

shRNA-H1 (Neg)-(blasticidin) lentivirus
H1(shRNA-Ctr)-Bsd	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made optional inducible lentiviral shRNA expression particles under human H1 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a Blasticidin marker under Rsv promoter.

shRNA-H1 (Neg)-(Puromycin) lentivirus
H1(shRNA-Ctr)-Puro	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made optional inducible lentiviral shRNA expression particles under human H1 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a Puromycin marker under Rsv promoter.

shRNA-U6 (Neg)-(blasticidin) lentivirus
U6(shRNA-Ctr)-Bsd	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made lentiviral shRNA expression particles under human U6 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a Blasticidin marker under Rsv promoter.

shRNA-U6 (Neg)-(Puromycin) lentivirus
U6(shRNA-Ctr)-Puro	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made lentiviral shRNA expression particles under human U6 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a Puromycin marker under Rsv promoter.

PAK4 Rabbit pAb
A11646-100ul	100 ul	EUR 369.6

PAK4 Rabbit pAb
A11646-200ul	200 ul	EUR 550.8

PAK4 Rabbit pAb
A11646-20ul	20 ul	EUR 219.6

PAK4 Rabbit pAb
A11646-50ul	50 ul	EUR 267.6

PAK4 Blocking Peptide
33R-10762	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PAK4 antibody, catalog no. 70R-11829

PAK4 Blocking Peptide
3444BP-50		EUR 183.6

PAK4 Blocking Peptide
33R-10491	50 ug	EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PAK4 antibody, catalog no. 20R-1576

PAK4 Rabbit pAb
A2782-100ul	100 ul	EUR 369.6

PAK4 Rabbit pAb
A2782-200ul	200 ul	EUR 550.8

PAK4 Rabbit pAb
A2782-20ul	20 ul	EUR 219.6

PAK4 Rabbit pAb
A2782-50ul	50 ul	EUR 267.6

PAK4 Polyclonal Antibody
A55818	100 µg	EUR 684.66
Description: fast delivery possible

PAK4 (pS474) Antibody
20-abx009814	EUR 376.80 EUR 560.40 EUR 243.60	100 ul 200 ul 30 ul

Mouse Pak4 Antibody
abx028063-400ul	400 ul	EUR 627.6

Mouse Pak4 Antibody
abx028063-80l	80 µl	EUR 343.2

Polyclonal PAK4 Antibody
APR00107G	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK4 . This antibody is tested and proven to work in the following applications:

Polyclonal PAK4 Antibody
APR06312G	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK4 . This antibody is tested and proven to work in the following applications:

PAK4 Blocking Peptide
DF7078-BP	1mg	EUR 234

PAK4 Conjugated Antibody
C35864	100ul	EUR 476.4

PAK4 Conjugated Antibody
C38462	100ul	EUR 476.4

PAK4 cloning plasmid
CSB-CL017408HU1-10ug	10ug	EUR 728.4
Description: A cloning plasmid for the PAK4 gene.

PAK4 cloning plasmid
CSB-CL017408HU2-10ug	10ug	EUR 279.6
Description: A cloning plasmid for the PAK4 gene.

Anti-PAK4 antibody
PAab06123	100 ug	EUR 426

anti- PAK4 antibody
FNab06123	100µg	EUR 606.3
Description: Antibody raised against PAK4

Anti-PAK4 antibody
STJ113249	100 µl	EUR 332.4
Description: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Anti-PAK4 antibody
STJ11100032	100 µl	EUR 495.6
Description: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Anti-PAK4 antibody
STJ24890	100 µl	EUR 332.4
Description: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

pCMV-SPORT6-PAK4
PVT12899	2 ug	EUR 469.2

pCMV-SPORT6-PAK4
PVT14106	2 ug	EUR 469.2

Anti-PAK4 (3F10)
YF-MA17239	100 ug	EUR 435.6
Description: Mouse monoclonal to PAK4

shRNA-H1 (Neg)-( GFP-Bsd) lentivirus
H1(shRNA-Ctr)-GB	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made optional inducible lentiviral shRNA expression particles under human H1 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a GFP-Blasticidin fusion marker under Rsv promoter.

shRNA-H1 (Neg)-( GFP-Puro) lentivirus
H1(shRNA-Ctr)-GP	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made optional inducible lentiviral shRNA expression particles under human H1 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a GFP-Puromycin fusion marker under Rsv promoter.

shRNA-H1 (Neg)-( RFP-Bsd) lentivirus
H1(shRNA-Ctr)-RB	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made optional inducible lentiviral shRNA expression particles under human H1 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a RFP-Blasticidin fusion marker under Rsv promoter.

shRNA-H1(Neg)-( RFP-Puro) lentivirus
H1(shRNA-Ctr)-RP	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made optional inducible lentiviral shRNA expression particles under human H1 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a RFP-puromycin fusion marker under Rsv promoter.

shRNA-U6 (Neg)-( GFP-Bsd) lentivirus
U6(shRNA-Ctr)-GB	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made lentiviral shRNA expression particles under human U6 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a GFP-Blasticidin fusion marker under Rsv promoter.

shRNA-U6 (Neg)-( GFP-Puro) lentivirus
U6(shRNA-Ctr)-GP	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made lentiviral shRNA expression particles under human U6 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a GFP-Puromycin fusion marker under Rsv promoter.

shRNA-U6 (Neg)-( RFP-Bsd) lentivirus
U6(shRNA-Ctr)-RB	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made lentiviral shRNA expression particles under human U6 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a RFP-Blasticidin fusion marker under Rsv promoter.

shRNA-U6 (Neg)-( RFP-Puro) lentivirus
U6(shRNA-Ctr)-RP	1 x107 IFU/ml x 200ul	EUR 418.8
Description: Pre-made lentiviral shRNA expression particles under human U6 promoter, containing a hairpin insert that should not knockdown any known human or mouse gene. This non-targeting control serves as a negative control for shRNA knockdown experiments. It also contains a RFP-puromycin fusion marker under Rsv promoter.

PAK4/5/6 antibody
70R-31507	100 ug	EUR 392.4
Description: Rabbit polyclonal PAK4/5/6 antibody

PAK4 (pS474) Blocking Peptide
20-abx063662	EUR 376.80 EUR 610.80	1 mg 5 mg

PAK4 protein (His tag)
80R-1077	100 ug	EUR 476.4
Description: Purified recombinant Human PAK4 protein

Polyclonal PAK4 Antibody (Internal)
APR02254G	0.05mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK4 (Internal). This antibody is tested and proven to work in the following applications:

PAK4 Antibody, HRP conjugated
1-CSB-PA05437B0Rb	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PAK4 Antibody, FITC conjugated
1-CSB-PA05437C0Rb	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PAK4 Antibody, Biotin conjugated
1-CSB-PA05437D0Rb	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Phospho-PAK4 (S474) Antibody
1-CSB-PA006474	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against Phospho-PAK4 (S474). Recognizes Phospho-PAK4 (S474) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

PAK4 ELISA KIT|Human
EF001536	96 Tests	EUR 826.8

PAK4 Polyclonal Antibody, HRP Conjugated
A55819	100 µg	EUR 684.66
Description: reagents widely cited

PAK4 Polyclonal Antibody, FITC Conjugated
A55820	100 µg	EUR 684.66
Description: Ask the seller for details

PAK4 Polyclonal Antibody, Biotin Conjugated
A55821	100 µg	EUR 684.66
Description: The best epigenetics products

PAK4 (phospho Ser474) Polyclonal Antibody
ABP53458-003ml	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of PAK4 phospho Ser474) from Human, Mouse, Rat. This PAK4 phospho Ser474) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the phosphorylation site of S474

PAK4 (phospho Ser474) Polyclonal Antibody
ABP53458-01ml	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of PAK4 phospho Ser474) from Human, Mouse, Rat. This PAK4 phospho Ser474) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the phosphorylation site of S474

PAK4 (phospho Ser474) Polyclonal Antibody
ABP53458-02ml	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of PAK4 phospho Ser474) from Human, Mouse, Rat. This PAK4 phospho Ser474) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the phosphorylation site of S474

PAK4/5/6 Polyclonal Antibody
ABP53459-003ml	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of PAK4/5/6 from Human, Mouse, Rat. This PAK4/5/6 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474

PAK4/5/6 Polyclonal Antibody
ABP53459-01ml	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of PAK4/5/6 from Human, Mouse, Rat. This PAK4/5/6 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474

PAK4/5/6 Polyclonal Antibody
ABP53459-02ml	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of PAK4/5/6 from Human, Mouse, Rat. This PAK4/5/6 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474

[KO Validated] PAK4 Rabbit pAb
A18059-100ul	100 ul	EUR 492

[KO Validated] PAK4 Rabbit pAb
A18059-200ul	200 ul	EUR 685.2

[KO Validated] PAK4 Rabbit pAb
A18059-20ul	20 ul	EUR 265.2

[KO Validated] PAK4 Rabbit pAb
A18059-50ul	50 ul	EUR 344.4

PAK4 / 5 / 6 (pS474) Antibody
abx217622-100ug	100 ug	EUR 526.8

PAK4 (phospho Ser474) Polyclonal Antibody
ES4457-100ul	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against PAK4 (phospho Ser474) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PAK4 (phospho Ser474) Polyclonal Antibody
ES4457-50ul	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against PAK4 (phospho Ser474) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PAK4/5/6 Polyclonal Antibody
ES4458-100ul	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against PAK4/5/6 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PAK4/5/6 Polyclonal Antibody
ES4458-50ul	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against PAK4/5/6 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Pak4 ORF Vector (Rat) (pORF)
ORF073068	1.0 ug DNA	EUR 607.2

PAK4 ORF Vector (Human) (pORF)
ORF007494	1.0 ug DNA	EUR 114

PAK4 ORF Vector (Human) (pORF)
ORF007495	1.0 ug DNA	EUR 114

Pak4 ORF Vector (Mouse) (pORF)
ORF053325	1.0 ug DNA	EUR 607.2

h PAK4 inducible lentiviral particles
LVP231	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made tet-inducible lentiviral particles expressing a human gene with a Blasticidin-RFP fusion marker (Dual selection). The expressed human gene, PAK4, is fully sequence verified and matched to NCBI accession ID: NM_001014831

PAK4 ELISA Kit (Human) (OKDD00452)
OKDD00452	96 Wells	EUR 1170
Description: Description of target: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.065 ng/mL

PAK4 ELISA Kit (Human) (OKCD00537)
OKCD00537	96 Wells	EUR 997.2
Description: Description of target: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.7 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.8"The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis."_x005F_x005F_x000D_Gnesutta N., Qu J., Minden A._x005F_x005F_x000D_J. Biol. Chem. 276:14414-14419(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF BAD.Ref.9"Activated PAK4 regulates cell adhesion and anchorage-independent growth."_x005F_x005F_x000D_Qu J., Cammarano M.S., Shi Q., Ha K.C., de Lanerolle P., Minden A._x005F_x005F_x000D_Mol. Cell. Biol. 21:3523-3533(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF SER-445 AND SER-474.Ref.11"Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4."_x005F_x005F_x000D_Gnesutta N., Minden A._x005F_x005F_x000D_Mol. Cell. Biol. 23:7838-7848(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.12"Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin."_x005F_x005F_x000D_Soosairajah J., Maiti S., Wiggan O., Sarmiere P., Moussi N., Sarcevic B., Sampath R., Bamburg J.R., Bernard O._x005F_x005F_x000D_EMBO J. 24:473-486(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.19"p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration."_x005F_x005F_x000D_Li Z., Zhang H., Lundin L., Thullberg M., Liu Y., Wang Y., Claesson-Welsh L., Stromblad S._x005F_x005F_x000D_J. Biol. Chem. 285:23699-23710(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF ITGB5.Ref.20"Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis."_x005F_x005F_x000D_Bompard G., Rabeharivelo G., Frank M., Cau J., Delsert C., Morin N._x005F_x005F_x000D_J. Cell Biol. 190:807-822(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF RAN.Ref.21"Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B."_x005F_x005F_x000D_Wallace S.W., Durgan J., Jin D., Hall A._x005F_x005F_x000D_Mol. Biol. Cell 21:2996-3006(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.065 ng/mL

Antibody for Human PAK4 (pSer474)
SPC-1044D	0.1ml	EUR 424.8
Description: A polyclonal antibody for PAK4 (pSer474) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Ser474 of human PAK4 (AA471-477). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PAK4 (pSer474) antibody is unconjugated.

Pak4 siRNA/shRNA/RNAi