Pak4 siRNA/shRNA/RNAi
To Order Contact us: lieven@wlsolutions.be
pROKII- RNAI Plasmid |
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PVT3202 | 2 ug | EUR 319.2 |
T7 RNAi Transcription Kit |
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TR102-01 | 25 rxn | EUR 307.2 |
T7 RNAi Transcription Kit |
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TR102-02 | 50 rxn | EUR 484.8 |
GeneGlide? RNAi Delivery Control |
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M1082-10 | each | EUR 284.4 |
GeneGlide? RNAi Delivery Control |
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M1082-100 | each | EUR 1002 |
GeneGlide? RNAi Delivery Control |
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M1082-50 | each | EUR 594 |
PAK4 |
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40076 | 10 µg | EUR 495 |
Description: Human PAK4 (GenBank Accession No. BC002921), a.a. 300-591, MW=33.3 kDa, expressed in E. coli. |
PAK1 siRNA |
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20-abx927641 |
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PAK1 siRNA |
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20-abx927642 |
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PAK2 siRNA |
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20-abx927643 |
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PAK2 siRNA |
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20-abx927644 |
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PAK3 siRNA |
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20-abx927645 |
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PAK3 siRNA |
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20-abx927646 |
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PAK6 siRNA |
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20-abx927649 |
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PAK6 siRNA |
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20-abx927650 |
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PAK7 siRNA |
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20-abx927651 |
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PAK7 siRNA |
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20-abx927652 |
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PAK2 siRNA |
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20-abx903828 |
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PAK3 siRNA |
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20-abx903829 |
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PAK7 siRNA |
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20-abx903830 |
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PAK1IP1 siRNA |
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20-abx927639 |
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PAK1IP1 siRNA |
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20-abx927640 |
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PAK4, Active |
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7707-5 | each | EUR 444 |
PAK4 Peptide |
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3077P | 0.05 mg | EUR 197.7 |
Description: (IN) PAK4 peptide |
PAK4 protein |
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30R-2822 | 5 ug | EUR 603.6 |
Description: Purified recombinant Human PAK4 protein |
PAK4 antibody |
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70R-11829 | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal PAK4 antibody |
PAK4 antibody |
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70R-19098 | 50 ul | EUR 522 |
Description: Rabbit polyclonal PAK4 antibody |
PAK4 Antibody |
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24183-100ul | 100ul | EUR 468 |
PAK4 antibody |
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70R-50787 | 100 ul | EUR 344.4 |
Description: Purified Polyclonal PAK4 antibody |
PAK4 Antibody |
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ABD7078 | 100 ug | EUR 525.6 |
PAK4 antibody |
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20R-1576 | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal PAK4 antibody |
PAK4 Antibody |
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3077-002mg | 0.02 mg | EUR 206.18 |
Description: PAK4 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways. |
PAK4 Antibody |
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3077-01mg | 0.1 mg | EUR 523.7 |
Description: PAK4 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways. |
PAK4 Antibody |
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35447-100ul | 100ul | EUR 468 |
PAK4 Antibody |
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3444-100 | each | EUR 398.4 |
PAK4 Antibody |
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3444-30T | each | EUR 175.2 |
PAK4 Antibody |
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35864-100ul | 100ul | EUR 302.4 |
PAK4 antibody |
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38462-100ul | 100ul | EUR 302.4 |
PAK4 Antibody |
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1-CSB-PA017408GA01HU |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF |
PAK4 Antibody |
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DF7078 | 200ul | EUR 420 |
PAK4 Antibody |
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1-CSB-PA038167 |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
PAK4 Antibody |
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1-CSB-PA006475 |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.IHC:1/200-1/1000.ELISA:1/40000 |
PAK4 Antibody |
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1-CSB-PA05437A0Rb |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:500 |
Pak4 Antibody |
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F43855-0.08ML | 0.08 ml | EUR 140.25 |
Description: Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity). |
Pak4 Antibody |
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F43855-0.4ML | 0.4 ml | EUR 322.15 |
Description: Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity). |
PAK4 Antibody |
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F50893-0.08ML | 0.08 ml | EUR 140.25 |
Description: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3, PAK4, PAK5, and PAK6. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. |
PAK4 Antibody |
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F50893-0.4ML | 0.4 ml | EUR 322.15 |
Description: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3, PAK4, PAK5, and PAK6. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. |
Rat PAK1 shRNA Plasmid |
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20-abx985493 |
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Rat PAK2 shRNA Plasmid |
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20-abx985494 |
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Rat PAK3 shRNA Plasmid |
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20-abx985495 |
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Rat PAK7 shRNA Plasmid |
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20-abx989675 |
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Mouse PAK7 shRNA Plasmid |
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20-abx982534 |
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Mouse PAK3 shRNA Plasmid |
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20-abx971921 |
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Human PAK1 shRNA Plasmid |
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20-abx953362 |
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Human PAK2 shRNA Plasmid |
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20-abx953363 |
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Human PAK3 shRNA Plasmid |
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20-abx953364 |
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Human PAK6 shRNA Plasmid |
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20-abx961226 |
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Human PAK7 shRNA Plasmid |
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20-abx961353 |
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Mouse PAK6 shRNA Plasmid |
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20-abx980853 |
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Mouse PAK2 shRNA Plasmid |
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20-abx981322 |
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pAd/BLOCK-iT-DEST RNAi Gateway Vector |
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PVT12297 | 2 ug | EUR 1342.8 |
Mouse PAK1IP1 shRNA Plasmid |
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20-abx976482 |
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Human PAK1IP1 shRNA Plasmid |
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20-abx960395 |
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PAK4 Rabbit pAb |
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A2782-100ul | 100 ul | EUR 369.6 |
PAK4 Rabbit pAb |
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A2782-200ul | 200 ul | EUR 550.8 |
PAK4 Rabbit pAb |
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A2782-20ul | 20 ul | EUR 219.6 |
PAK4 Rabbit pAb |
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A2782-50ul | 50 ul | EUR 267.6 |
PAK4 Rabbit pAb |
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A11646-100ul | 100 ul | EUR 369.6 |
PAK4 Rabbit pAb |
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A11646-200ul | 200 ul | EUR 550.8 |
PAK4 Rabbit pAb |
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A11646-20ul | 20 ul | EUR 219.6 |
PAK4 Rabbit pAb |
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A11646-50ul | 50 ul | EUR 267.6 |
anti- PAK4 antibody |
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FNab06123 | 100µg | EUR 606.3 |
Description: Antibody raised against PAK4 |
PAK4 (pS474) Antibody |
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20-abx009814 |
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Mouse Pak4 Antibody |
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abx028063-400ul | 400 ul | EUR 627.6 |
Mouse Pak4 Antibody |
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abx028063-80l | 80 µl | EUR 343.2 |
PAK4 cloning plasmid |
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CSB-CL017408HU1-10ug | 10ug | EUR 728.4 |
Description: A cloning plasmid for the PAK4 gene. |
PAK4 cloning plasmid |
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CSB-CL017408HU2-10ug | 10ug | EUR 279.6 |
Description: A cloning plasmid for the PAK4 gene. |
PAK4 Blocking Peptide |
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3444BP-50 | each | EUR 183.6 |
PAK4 Blocking Peptide |
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33R-10491 | 50 ug | EUR 418.8 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PAK4 antibody, catalog no. 20R-1576 |
PAK4 Blocking Peptide |
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33R-10762 | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PAK4 antibody, catalog no. 70R-11829 |
PAK4 Blocking Peptide |
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DF7078-BP | 1mg | EUR 234 |
PAK4 Polyclonal Antibody |
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A55818 |
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PAK4 Polyclonal Antibody |
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A73364 |
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PAK4 Polyclonal Antibody |
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A71624 |
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PAK4 Polyclonal Antibody |
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A71625 |
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Polyclonal PAK4 Antibody |
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APR06312G | 0.1 mg | EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK4 . This antibody is tested and proven to work in the following applications: |
Polyclonal PAK4 Antibody |
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APR00107G | 0.1mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK4 . This antibody is tested and proven to work in the following applications: |
PAK4 Conjugated Antibody |
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C35864 | 100ul | EUR 476.4 |
PAK4 Conjugated Antibody |
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C38462 | 100ul | EUR 476.4 |
PAK4/5/6 antibody |
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70R-31507 | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal PAK4/5/6 antibody |
PAK4 protein (His tag) |
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80R-1077 | 100 ug | EUR 476.4 |
Description: Purified recombinant Human PAK4 protein |
PAK4 ELISA KIT|Human |
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EF001536 | 96 Tests | EUR 826.8 |
PAK4 (pS474) Blocking Peptide |
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20-abx063662 |
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PAK4 Antibody, HRP conjugated |
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1-CSB-PA05437B0Rb |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
PAK4 Antibody, FITC conjugated |
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1-CSB-PA05437C0Rb |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
PAK4 Antibody, Biotin conjugated |
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1-CSB-PA05437D0Rb |
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Description: A polyclonal antibody against PAK4. Recognizes PAK4 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Polyclonal PAK4 Antibody (Internal) |
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APR02254G | 0.05mg | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PAK4 (Internal). This antibody is tested and proven to work in the following applications: |
Pak4 ORF Vector (Rat) (pORF) |
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ORF073068 | 1.0 ug DNA | EUR 607.2 |
PAK4 / 5 / 6 (pS474) Antibody |
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abx217622-100ug | 100 ug | EUR 526.8 |
PAK4 ORF Vector (Human) (pORF) |
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ORF007494 | 1.0 ug DNA | EUR 114 |
PAK4 ORF Vector (Human) (pORF) |
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ORF007495 | 1.0 ug DNA | EUR 114 |
Pak4 ORF Vector (Mouse) (pORF) |
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ORF053325 | 1.0 ug DNA | EUR 607.2 |
[KO Validated] PAK4 Rabbit pAb |
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A18059-100ul | 100 ul | EUR 492 |
[KO Validated] PAK4 Rabbit pAb |
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A18059-200ul | 200 ul | EUR 685.2 |
[KO Validated] PAK4 Rabbit pAb |
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A18059-20ul | 20 ul | EUR 265.2 |
[KO Validated] PAK4 Rabbit pAb |
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A18059-50ul | 50 ul | EUR 344.4 |
PAK4/5/6 Polyclonal Antibody |
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ABP53459-003ml | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of PAK4/5/6 from Human, Mouse, Rat. This PAK4/5/6 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474 |
PAK4/5/6 Polyclonal Antibody |
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ABP53459-01ml | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of PAK4/5/6 from Human, Mouse, Rat. This PAK4/5/6 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474 |
PAK4/5/6 Polyclonal Antibody |
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ABP53459-02ml | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of PAK4/5/6 from Human, Mouse, Rat. This PAK4/5/6 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474 |
PAK4 ELISA Kit (Human) (OKCD00537) |
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OKCD00537 | 96 Wells | EUR 997.2 |
Description: Description of target: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.7 Publications
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.8"The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis."_x005F_x005F_x000D_Gnesutta N., Qu J., Minden A._x005F_x005F_x000D_J. Biol. Chem. 276:14414-14419(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF BAD.Ref.9"Activated PAK4 regulates cell adhesion and anchorage-independent growth."_x005F_x005F_x000D_Qu J., Cammarano M.S., Shi Q., Ha K.C., de Lanerolle P., Minden A._x005F_x005F_x000D_Mol. Cell. Biol. 21:3523-3533(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF SER-445 AND SER-474.Ref.11"Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4."_x005F_x005F_x000D_Gnesutta N., Minden A._x005F_x005F_x000D_Mol. Cell. Biol. 23:7838-7848(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.12"Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin."_x005F_x005F_x000D_Soosairajah J., Maiti S., Wiggan O., Sarmiere P., Moussi N., Sarcevic B., Sampath R., Bamburg J.R., Bernard O._x005F_x005F_x000D_EMBO J. 24:473-486(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.19"p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration."_x005F_x005F_x000D_Li Z., Zhang H., Lundin L., Thullberg M., Liu Y., Wang Y., Claesson-Welsh L., Stromblad S._x005F_x005F_x000D_J. Biol. Chem. 285:23699-23710(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF ITGB5.Ref.20"Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis."_x005F_x005F_x000D_Bompard G., Rabeharivelo G., Frank M., Cau J., Delsert C., Morin N._x005F_x005F_x000D_J. Cell Biol. 190:807-822(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF RAN.Ref.21"Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B."_x005F_x005F_x000D_Wallace S.W., Durgan J., Jin D., Hall A._x005F_x005F_x000D_Mol. Biol. Cell 21:2996-3006(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.065 ng/mL |
PAK4 ELISA Kit (Human) (OKDD00452) |
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OKDD00452 | 96 Wells | EUR 1170 |
Description: Description of target: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.065 ng/mL |
PAK4/5/6 Polyclonal Antibody |
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ES4458-100ul | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against PAK4/5/6 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |