Recombinant Human Anti-Siglec-15

Recombinant Human Anti-Siglec-15 

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Human Siglec-15 Protein (Phe 20-Thr 263) [Fc]
VAng-2703Lsx-100g	100 µg	EUR 1215.6
Description: Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Human Siglec-15 Protein (Phe 20-Thr 263) [Fc]
VAng-2703Lsx-1mg	1 mg	EUR 7682.4
Description: Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Human Siglec-15 Protein (Phe 20-Thr 263) [His]
VAng-2709Lsx-100g	100 µg	EUR 1215.6
Description: Human Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Human Siglec-15 Protein (Phe 20-Thr 263) [His]
VAng-2709Lsx-1mg	1 mg	EUR 7682.4
Description: Human Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	50 µg	EUR 418.8

Liquid Wicks, Size 15, 200 /pk
W-15	200 WICKS	EUR 22
Description: Liquid Wicks, Size 15, 200 /pk

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3
CW37-10ug	10ug	EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3
CW37-1mg	1mg	EUR 3274.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3
CW37-500ug	500ug	EUR 2312.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3
CW37-50ug	50ug	EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

AXYGEN® HORIZONTAL GEL BOX, 15 CM
HGB-15	1/pk	EUR 583.2
Description: Lab Equipment; Axygen Branded EQ

DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm
GFL-15	1 mL	EUR 1263.6

Siglec-3 Recombinant Protein
91-401	0.05 mg	EUR 556.8
Description: CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.

Siglec 9 Recombinant Protein
91-630	0.05 mg	EUR 588.3
Description: Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils), and found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Siglec-3 Recombinant Protein
92-412	0.05 mg	EUR 651.3
Description: Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia. CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).

Siglec-9 Recombinant Protein
11-268	0.1 mg	EUR 714.3
Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Siglec-10 Recombinant Protein
11-269	0.1 mg	EUR 821.4
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein
11-275	0.1 mg	EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein
11-278	0.1 mg	EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-9 Recombinant Protein
11-298	0.1 mg	EUR 714.3
Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Siglec-9 Recombinant Protein
11-300	0.1 mg	EUR 714.3
Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Siglec-8 Recombinant Protein
11-317	0.1 mg	EUR 714.3
Description: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8 Recombinant Protein
11-319	0.1 mg	EUR 714.3
Description: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-10 Recombinant Protein
11-411	0.1 mg	EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein
11-190	0.1 mg	EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT
HGB15-15-GT	1/pk	EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

DiagNano Gold Nanoparticle Passive Conjugation Kit, 15 nm
GPK-15	1 kit	EUR 858

Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [His]
VAng-2704Lsx-100g	100 µg	EUR 1215.6
Description: Cynomolgus Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1)

Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [His]
VAng-2704Lsx-1mg	1 mg	EUR 7682.4
Description: Cynomolgus Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1)

Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [Fc]
VAng-2705Lsx-100g	100 µg	EUR 1215.6
Description: Cynomolgus Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1)

Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [Fc]
VAng-2705Lsx-1mg	1 mg	EUR 7682.4
Description: Cynomolgus Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1)

Mouse Siglec-15 Protein (Arg 24-Thr 262) [His]
VAng-2707Lsx-100g	100 µg	EUR 1215.6
Description: Mouse Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A7E1W8-1)

Mouse Siglec-15 Protein (Arg 24-Thr 262) [His]
VAng-2707Lsx-1mg	1 mg	EUR 7682.4
Description: Mouse Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A7E1W8-1)

Anti-Siglec-5/14 Antibody
A06510-1	100ul	EUR 476.4
Description: Rabbit Polyclonal Antibody for Siglec-5/14 Antibody (SIGLEC5) detection.tested for IHC, WB in Human.

Anti-Siglec-5/14 antibody
STJ96635	200 µl	EUR 236.4
Description: Rabbit polyclonal to Siglec-5/14.

Recombinant Human CD33/Siglec-3 Protein
RP00159	20 μg	EUR 219.6

Recombinant Human MAG/Siglec-4a Protein
RP00424	10 μg	EUR 219.6

Recombinant human Siglec-9/CD329 Protein
RP01193	10 μg	EUR 276

Recombinant human Siglec-5/CD170 Protein
RP01196	20 μg	EUR 231.6

Recombinant human Siglec-2/CD22 Protein
RP01199	10 μg	EUR 186

Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [Fc] [Avi]
VAng-2706Lsx-200g	200 µg	EUR 4612.8
Description: Biotinylated Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [Fc] [Avi]
VAng-2706Lsx-25g	25 µg	EUR 1215.6
Description: Biotinylated Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [His] [Avi]
VAng-2708Lsx-200g	200 µg	EUR 4612.8
Description: Biotinylated Human Siglec-15 (CD33L3) protein, His tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [His] [Avi]
VAng-2708Lsx-25g	25 µg	EUR 1215.6
Description: Biotinylated Human Siglec-15 (CD33L3) protein, His tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1)

Anti-Human IgG
DB173RTU-15	15 ml	EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human IgG
DB174RTU-15	15 ml	EUR 426
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Human CellExp? CD33 / SIGLEC-3, human recombinant
7370-10	each	EUR 320.4

Human CellExp? CD33 / SIGLEC-3, human recombinant
7370-50	each	EUR 861.6

Normal Rabbit Serum | RS-15-100ML
RS-15-100ML	100 mL	EUR 420
Description: Normal Rabbit Serum | RS-15-100ML | Immunology Consultants Laboratory Species Reactivity: Rabbit Format: Serum Product Type: Isotype Control Antibody clonality: Polyclonal

MAG / Siglec-4a Recombinant Protein
11-288	0.1 mg	EUR 651.3
Description: Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

MAG / Siglec-4a Recombinant Protein
11-289	0.1 mg	EUR 651.3
Description: Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

Recombinant Human Anti-Siglec-15