Recombinant Human Anti-Siglec-15

Recombinant Human Anti-Siglec-15 

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Recombinant human Siglec-9/CD329 Protein

RP01193 10 μg
EUR 276

Recombinant human Siglec-5/CD170 Protein

RP01196 20 μg
EUR 231.6

Human CellExp? CD33 / SIGLEC-3, human recombinant

7370-10 each
EUR 320.4

Human CellExp? CD33 / SIGLEC-3, human recombinant

7370-50 each
EUR 861.6

Siglec-10 Recombinant Protein

11-190 0.1 mg
EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein

11-269 0.1 mg
EUR 821.4
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein

11-275 0.1 mg
EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein

11-278 0.1 mg
EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 Recombinant Protein

11-411 0.1 mg
EUR 714.3
Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3

CW37-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3

CW37-1mg 1mg
EUR 3274.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3

CW37-500ug 500ug
EUR 2312.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3

CW37-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Siglec-9 Recombinant Protein

11-268 0.1 mg
EUR 714.3
Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Siglec-9 Recombinant Protein

11-298 0.1 mg
EUR 714.3
Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Siglec-9 Recombinant Protein

11-300 0.1 mg
EUR 714.3
Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

Siglec-8 Recombinant Protein

11-317 0.1 mg
EUR 714.3
Description: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8 Recombinant Protein

11-319 0.1 mg
EUR 714.3
Description: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-3 Recombinant Protein

91-401 0.05 mg
EUR 556.8
Description: CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.

Siglec-3 Recombinant Protein

92-412 0.05 mg
EUR 651.3
Description: Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia. CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).

Human CellExp? Siglec-2 / CD22, Mouse Recombinant

P1330-10 each
EUR 183.6

Human CellExp? Siglec-2 / CD22, Mouse Recombinant

P1330-50 each
EUR 510

Siglec 9 Recombinant Protein

91-630 0.05 mg
EUR 588.3
Description: Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils), and found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Human CellExp? CD33 / SIGLEC-3, Fc Tag, Human Recombinant

P1334-10 each
EUR 170.4

Human CellExp? CD33 / SIGLEC-3, Fc Tag, Human Recombinant

P1334-50 each
EUR 523.2

MAG / Siglec-4a Recombinant Protein

11-288 0.1 mg
EUR 651.3
Description: Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

MAG / Siglec-4a Recombinant Protein

11-289 0.1 mg
EUR 651.3
Description: Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

Siglec-2 / CD22 Recombinant Protein

11-455 0.1 mg
EUR 651.3
Description: B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Siglec-1 / CD169 Recombinant Protein

11-194 0.1 mg
EUR 714.3
Description: Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells.

Human Siglec-10 Recombinant Protein Fc Tag Lyophilized

IHUSIGLEC10RFCLY100UG each
EUR 851
Description: Human Siglec-10 Recombinant Protein Fc Tag Lyophilized

Human Siglec-10 Recombinant Protein His Tag Lyophilized

IHUSIGLEC10RHISLY100UG each
EUR 851
Description: Human Siglec-10 Recombinant Protein His Tag Lyophilized

Human Siglec-8 Recombinant Protein Fc Tag Lyophilized

IHUSIGLEC8RFCLY100UG each
EUR 851
Description: Human Siglec-8 Recombinant Protein Fc Tag Lyophilized

Human Siglec-9 Recombinant Protein Fc Tag Lyophilized

IHUSIGLEC9RFCLY100UG each
EUR 851
Description: Human Siglec-9 Recombinant Protein Fc Tag Lyophilized

Human CellExp? Siglec-2 / CD22 isoform beta, Human Recombinant

P1171-10 each
EUR 183.6

Human CellExp? Siglec-2 / CD22 isoform beta, Human Recombinant

P1171-50 each
EUR 510

Human Siglec-8 Recombinant Protein His Tag Lyophilized

IHUSIGLEC8RHISLY100UG each
EUR 851
Description: Human Siglec-8 Recombinant Protein His Tag Lyophilized

Human Siglec-9 Recombinant Protein His Tag Lyophilized

IHUSIGLEC9RHISLY100UG each
EUR 851
Description: Human Siglec-9 Recombinant Protein His Tag Lyophilized

Recombinant Human MAG/ GMA/ Siglec-4 Protein, His, Yeast-1mg

QP6332-ye-1mg 1mg
EUR 2262

Recombinant Human MAG/ GMA/ Siglec-4 Protein, His, Yeast-10ug

QP6332-ye-10ug 10ug
EUR 283.2

Recombinant Human MAG/ GMA/ Siglec-4 Protein, His, Yeast-50ug

QP6332-ye-50ug 50ug
EUR 358.8

Recombinant Human MAG/ GMA/ Siglec-4 Protein, His, Yeast-100ug

QP6332-ye-100ug 100ug
EUR 576

Recombinant Human MAG/ GMA/ Siglec-4 Protein, His, Yeast-200ug

QP6332-ye-200ug 200ug
EUR 892.8

Recombinant Human MAG/ GMA/ Siglec-4 Protein, His, Yeast-500ug

QP6332-ye-500ug 500ug
EUR 1447.2

Human MAG / Siglec-4a Recombinant Protein Fc Tag Lyophilized

IHUMAGSIGLEC4ARFCLY100UG each
EUR 762
Description: Human MAG / Siglec-4a Recombinant Protein Fc Tag Lyophilized

Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-Fc)

CC09-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-Fc)

CC09-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-Fc)

CC09-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-Fc)

CC09-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Human Siglec-2 / CD22 Recombinant Protein His Tag Lyophilized

IHUSIGLEC2CD22RHISLY100UG each
EUR 762
Description: Human Siglec-2 / CD22 Recombinant Protein His Tag Lyophilized

Human Siglec-7 Recombinant Protein C-6His Tag Lyophilized

IHUSIGLEC7RC6HISLY10UG each
EUR 388
Description: Human Siglec-7 Recombinant Protein C-6His Tag Lyophilized

Human MAG / Siglec-4a Recombinant Protein His Tag Lyophilized

IHUMAGSIGLEC4ARHISLY100UG each
EUR 762
Description: Human MAG / Siglec-4a Recombinant Protein His Tag Lyophilized

Recombinant Human Anti-Siglec-15