Recombinant Human Anti-Siglec-15
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Human Siglec-15 Protein (Phe 20-Thr 263) [Fc] |
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| VAng-2703Lsx-1mg | 1 mg | EUR 7682.4 |
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Description: Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Human Siglec-15 Protein (Phe 20-Thr 263) [His] |
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| VAng-2709Lsx-100g | 100 µg | EUR 1215.6 |
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Description: Human Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Human Siglec-15 Protein (Phe 20-Thr 263) [His] |
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| VAng-2709Lsx-1mg | 1 mg | EUR 7682.4 |
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Description: Human Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | 50 µg | EUR 418.8 |
Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3 |
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| CW37-10ug | 10ug | EUR 187.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3 |
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| CW37-1mg | 1mg | EUR 3274.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3 |
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| CW37-500ug | 500ug | EUR 2312.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33 antigen-like 3/CD33L3 |
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| CW37-50ug | 50ug | EUR 363.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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AXYGEN® HORIZONTAL GEL BOX, 15 CM |
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| HGB-15 | 1/pk | EUR 583.2 |
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Description: Lab Equipment; Axygen Branded EQ |
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DiagNano Fluorophore Labeled Gold Nanoparticles, 15 nm |
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| GFL-15 | 1 mL | EUR 1263.6 |
AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT |
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| HGB15-15-GT | 1/pk | EUR 94.8 |
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Description: Lab Equipment; Axygen Branded EQ |
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DiagNano Gold Nanoparticle Passive Conjugation Kit, 15 nm |
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| GPK-15 | 1 kit | EUR 858 |
Siglec-3 Recombinant Protein |
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| 91-401 | 0.05 mg | EUR 556.8 |
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Description: CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation. |
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Siglec 9 Recombinant Protein |
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| 91-630 | 0.05 mg | EUR 588.3 |
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Description: Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils), and found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
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Siglec-3 Recombinant Protein |
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| 92-412 | 0.05 mg | EUR 651.3 |
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Description: Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia. CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML). |
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Siglec-9 Recombinant Protein |
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| 11-268 | 0.1 mg | EUR 714.3 |
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Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. |
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Siglec-10 Recombinant Protein |
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| 11-269 | 0.1 mg | EUR 821.4 |
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Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products. |
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Siglec-10 Recombinant Protein |
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| 11-275 | 0.1 mg | EUR 714.3 |
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Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products. |
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Siglec-10 Recombinant Protein |
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| 11-278 | 0.1 mg | EUR 714.3 |
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Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products. |
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Siglec-9 Recombinant Protein |
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| 11-298 | 0.1 mg | EUR 714.3 |
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Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. |
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Siglec-9 Recombinant Protein |
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| 11-300 | 0.1 mg | EUR 714.3 |
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Description: siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. |
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Siglec-8 Recombinant Protein |
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| 11-317 | 0.1 mg | EUR 714.3 |
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Description: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region. |
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Siglec-8 Recombinant Protein |
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| 11-319 | 0.1 mg | EUR 714.3 |
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Description: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region. |
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Siglec-10 Recombinant Protein |
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| 11-411 | 0.1 mg | EUR 714.3 |
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Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products. |
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Siglec-10 Recombinant Protein |
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| 11-190 | 0.1 mg | EUR 714.3 |
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Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products. |
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Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [His] |
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| VAng-2704Lsx-100g | 100 µg | EUR 1215.6 |
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Description: Cynomolgus Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1) |
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Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [His] |
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| VAng-2704Lsx-1mg | 1 mg | EUR 7682.4 |
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Description: Cynomolgus Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1) |
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Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [Fc] |
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| VAng-2705Lsx-100g | 100 µg | EUR 1215.6 |
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Description: Cynomolgus Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1) |
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Cynomolgus Siglec-15 Protein (Phe 20-Thr 263) [Fc] |
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| VAng-2705Lsx-1mg | 1 mg | EUR 7682.4 |
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Description: Cynomolgus Siglec-15 (CD33L3) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: A0A2K5UY47-1) |
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Mouse Siglec-15 Protein (Arg 24-Thr 262) [His] |
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| VAng-2707Lsx-100g | 100 µg | EUR 1215.6 |
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Description: Mouse Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A7E1W8-1) |
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Mouse Siglec-15 Protein (Arg 24-Thr 262) [His] |
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| VAng-2707Lsx-1mg | 1 mg | EUR 7682.4 |
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Description: Mouse Siglec-15 (CD33L3) protein, His tag, was expressed in human 293 cells. (Uniprot ID: A7E1W8-1) |
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Anti-Siglec-5/14 Antibody |
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| A06510-1 | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Antibody for Siglec-5/14 Antibody (SIGLEC5) detection.tested for IHC, WB in Human. |
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Anti-Siglec-5/14 antibody |
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| STJ96635 | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to Siglec-5/14. |
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Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [Fc] [Avi] |
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| VAng-2706Lsx-200g | 200 µg | EUR 4612.8 |
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Description: Biotinylated Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [Fc] [Avi] |
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| VAng-2706Lsx-25g | 25 µg | EUR 1215.6 |
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Description: Biotinylated Human Siglec-15 (CD33L3) protein, human IgG1 Fc tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [His] [Avi] |
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| VAng-2708Lsx-200g | 200 µg | EUR 4612.8 |
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Description: Biotinylated Human Siglec-15 (CD33L3) protein, His tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Biotinylated Human Siglec-15 Protein (Phe 20-Thr 263) [His] [Avi] |
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| VAng-2708Lsx-25g | 25 µg | EUR 1215.6 |
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Description: Biotinylated Human Siglec-15 (CD33L3) protein, His tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: Q6ZMC9-1) |
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Recombinant Human CD33/Siglec-3 Protein |
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| RP00159 | 20 μg | EUR 219.6 |
Recombinant Human MAG/Siglec-4a Protein |
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| RP00424 | 10 μg | EUR 219.6 |
Recombinant human Siglec-9/CD329 Protein |
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| RP01193 | 10 μg | EUR 276 |
Recombinant human Siglec-5/CD170 Protein |
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| RP01196 | 20 μg | EUR 231.6 |
Recombinant human Siglec-2/CD22 Protein |
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| RP01199 | 10 μg | EUR 186 |
Anti-Human IgG |
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| DB173RTU-15 | 15 ml | EUR 426 |
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Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
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Anti-Human IgG |
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| DB174RTU-15 | 15 ml | EUR 426 |
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Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
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Human CellExp? CD33 / SIGLEC-3, human recombinant |
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| 7370-10 | EUR 320.4 | |
Human CellExp? CD33 / SIGLEC-3, human recombinant |
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| 7370-50 | EUR 861.6 | |
MAG / Siglec-4a Recombinant Protein |
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| 11-288 | 0.1 mg | EUR 651.3 |
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Description: Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. |
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MAG / Siglec-4a Recombinant Protein |
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| 11-289 | 0.1 mg | EUR 651.3 |
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Description: Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. |
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Siglec-2 / CD22 Recombinant Protein |
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| 11-455 | 0.1 mg | EUR 651.3 |
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Description: B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
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Siglec-1 / CD169 Recombinant Protein |
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| 11-194 | 0.1 mg | EUR 714.3 |
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Description: Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. |
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Anti-Siglec-H Antibody (Monoclonal, ABM2B55) |
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| M30285 | 100 ug | EUR 476.4 |
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Description: Rat Monoclonal Siglec-H Antibody (Monoclonal, ABM2B55). Validated in WB and tested in Mouse. |
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